(PDB: 1S2M structure)
DEAD box helicase family

FEATURES

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Members	Human proteins	All
Members	60	1438
Drug targets	0	0
With known 3D structures	30	55
With tested compounds	4	6
With active compounds (<100nM)	1	1
With mutations reported	58	58

DEAD box helicase family

Lineage

Family DEAD box helicase family

4 members not classified in subfamilies

DDX25 ,DDX28 ,DDX43 ,DDX53

28 subfamilies

Subfamily DDX10/DBP4 subfamily

1 member

Subfamily DDX18/HAS1 subfamily

1 member

Subfamily DDX19/DBP5 subfamily

2 members

Subfamily DDX1 subfamily

1 member

Subfamily DDX20 subfamily

1 member

Subfamily DDX21/DDX50 subfamily

2 members

Subfamily DDX23/PRP28 subfamily

1 member

Subfamily DDX24/MAK5 subfamily

1 member

Subfamily DDX27/DRS1 subfamily

1 member

Subfamily DDX31/DBP7 subfamily

1 member

Subfamily DDX3/DED1 subfamily

2 members

Subfamily DDX41 subfamily

1 member

Subfamily DDX42 subfamily

1 member

Subfamily DDX46/PRP5 subfamily

1 member

Subfamily DDX47/RRP3 subfamily

1 member

Subfamily DDX49/DBP8 subfamily

1 member

Subfamily DDX4/VASA subfamily

1 member

Subfamily DDX51/DBP6 subfamily

1 member

Subfamily DDX52/ROK1 subfamily

1 member

Subfamily DDX54/DBP10 subfamily

1 member

Subfamily DDX55/SPB4 subfamily

1 member

Subfamily DDX56/DBP9 subfamily

1 member

Subfamily DDX59 subfamily

1 member

Subfamily DDX5/DBP2 subfamily

2 members

Subfamily DDX6/DHH1 subfamily

1 member

Subfamily DEAH subfamily

14 members not classified in sub-subfamilies

6 sub-subfamilies

Sub-subfamily DDX11/CHL1 sub-subfamily

3 members

DDX11 ,DDX11L8 ,DDX12P

Sub-subfamily DDX15/PRP43 sub-subfamily

1 member

Sub-subfamily DDX16/PRP8 sub-subfamily

1 member

Sub-subfamily DDX8/PRP22 sub-subfamily

1 member

Sub-subfamily FANCM sub-subfamily

1 member

Sub-subfamily PRP16 sub-subfamily

1 member

Subfamily DECD subfamily

2 members

Subfamily eIF4A subfamily

3 members

EIF4A1 ,EIF4A2 ,EIF4A3