(PDB: 1S2M structure)
DEAD box helicase family

FEATURES

Members	Human proteins	All
Members	60	1438
Drug targets	0	0
With known 3D structures	30	55
With tested compounds	4	6
With active compounds (<100nM)	1	1
With mutations reported	58	58

DEAD box helicase family

Lineage

Family DEAD box helicase family (60 members)

4 members not classified in subfamilies

DDX25 , DDX28 , DDX43 , DDX53

28 subfamilies

Subfamily DDX10/DBP4 subfamily (1 member)

1 member

Subfamily DDX18/HAS1 subfamily (1 member)

1 member

Subfamily DDX19/DBP5 subfamily (2 members)

2 members

DDX19A , DDX19B

Subfamily DDX1 subfamily (1 member)

1 member

Subfamily DDX20 subfamily (1 member)

1 member

Subfamily DDX21/DDX50 subfamily (2 members)

2 members

Subfamily DDX23/PRP28 subfamily (1 member)

1 member

Subfamily DDX24/MAK5 subfamily (1 member)

1 member

Subfamily DDX27/DRS1 subfamily (1 member)

1 member

Subfamily DDX31/DBP7 subfamily (1 member)

1 member

Subfamily DDX3/DED1 subfamily (2 members)

2 members

Subfamily DDX41 subfamily (1 member)

1 member

Subfamily DDX42 subfamily (1 member)

1 member

Subfamily DDX46/PRP5 subfamily (1 member)

1 member

Subfamily DDX47/RRP3 subfamily (1 member)

1 member

Subfamily DDX49/DBP8 subfamily (1 member)

1 member

Subfamily DDX4/VASA subfamily (1 member)

1 member

Subfamily DDX51/DBP6 subfamily (1 member)

1 member

Subfamily DDX52/ROK1 subfamily (1 member)

1 member

Subfamily DDX54/DBP10 subfamily (1 member)

1 member

Subfamily DDX55/SPB4 subfamily (1 member)

1 member

Subfamily DDX56/DBP9 subfamily (1 member)

1 member

Subfamily DDX59 subfamily (1 member)

1 member

Subfamily DDX5/DBP2 subfamily (2 members)

2 members

Subfamily DDX6/DHH1 subfamily (1 member)

1 member

Subfamily DEAH subfamily (22 members)

14 members not classified in sub-subfamilies

6 sub-subfamilies

Sub-subfamily DDX11/CHL1 sub-subfamily ( members)

3 members

DDX11 , DDX11L8 , DDX12P

Sub-subfamily DDX15/PRP43 sub-subfamily ( members)

1 member

Sub-subfamily DDX16/PRP8 sub-subfamily ( members)

1 member

Sub-subfamily DDX8/PRP22 sub-subfamily ( members)

1 member

Sub-subfamily FANCM sub-subfamily ( members)

1 member

Sub-subfamily PRP16 sub-subfamily ( members)

1 member

Subfamily DECD subfamily (2 members)

2 members

DDX39A , DDX39B

Subfamily eIF4A subfamily (3 members)

3 members

EIF4A1 , EIF4A2 , EIF4A3