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GENERAL
TITLE
DISCOVERY OF XL335, A HIGHLY POTENT, SELECTIVE AND ORALLY- ACTIVE AGONIST OF THE FARNESOID X RECEPTOR (FXR)
DATE LAST MODIFIED
-
RELEASE
22 Dec 2009
OBSOLETE
CLASSIFICATION
TRANSCRIPTION
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 41 21 2
RESOLUTION RANGE HIGH
2
RESOLUTION RANGE LOW
66.519
PUBMED ID
DOI
10.1021/JM8014124
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q96RI1 BAR, FXR, HRR1, NR1H4, RIP14 ESCHERICHIA COLI HUMAN
FARNESOID X-ACTIVATED RECEPTOR, FARNESOL RECEPTORH ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402