4H3G

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 4H3G_A

Chain 4H3G_B

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GENERAL

TITLE

STRUCTURE OF BACE BOUND TO 2-((7AR)-7A-(4-(3-CYANOPHENYL)THIOPHEN-2- YL)-2-IMINO-3-METHYL-4-OXOHEXAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDIN-6(2H)- YL)NICOTINONITRILE

DATE LAST MODIFIED

21 Nov 2012

RELEASE

7 Nov 2012

OBSOLETE

CLASSIFICATION

HYDROLASE/HYDROLASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 21

RESOLUTION RANGE HIGH

1.85

RESOLUTION RANGE LOW

PUBMED ID

22989333

DOI

10.1021/JM301039C

PDBe

4H3G

LIGANDS

67113

Chains

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P56817	BACE, BACE1, KIAA1149	ESCHERICHIA COLI	HUMAN	ASPARTYL PROTEASE 2, ASP2, ASP 2, BETA-SITE AMYLOI ...	Mutations
	P56817	BACE, BACE1, KIAA1149	ESCHERICHIA COLI	HUMAN	ASPARTYL PROTEASE 2, ASP2, ASP 2, BETA-SITE AMYLOI ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402