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GENERAL
TITLE
CRYSTAL STRUCTURE OF FGFR1 (C488A, C584S) IN COMPLEX WITH AZD4547 (N- {3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5- DIMETHYLPIPERAZIN-1-YL]BENZAMIDE)
DATE LAST MODIFIED
22 Nov 2017
RELEASE
22 Apr 2015
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
2.489
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACSCHEMBIO.5B00014
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P0A7S9 BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR ESCHERICHIA COLI HUMAN
FGFR-1, BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1, ...
P0A7V3 BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR ESCHERICHIA COLI HUMAN
FGFR-1, BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1, ...
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402