4XT2

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 4XT2_1

Bioassembly 4XT2_2

Chain 4XT2_A

Chain 4XT2_B

Chain 4XT2_C

Chain 4XT2_D

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GENERAL

TITLE

CRYSTAL STRUCTURE OF THE HIGH AFFINITY HETERODIMER OF HIF2 ALPHA AND ARNT C-TERMINAL PAS DOMAINS IN COMPLEX WITH A TETRAZOLE-CONTAINING ANTAGONIST

DATE LAST MODIFIED

4 Dec 2019

RELEASE

9 Dec 2015

OBSOLETE

CLASSIFICATION

TRANSCRIPTION

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

C 1 2 1

RESOLUTION RANGE HIGH

1.698

RESOLUTION RANGE LOW

PUBMED ID

DOI

10.1021/ACS.JMEDCHEM.5B00529

PDBe

LIGANDS

Chains

Target Protein	Gene	Expression System	Organism	Synonims	Actions
Q99814	EPAS1, BHLHE73, HIF2A, MOP2, PASD2	ESCHERICHIA COLI BL21(DE3)	HUMAN	EPAS-1, BASIC-HELIX-LOOP-HELIX-PAS PROTEIN MOP2, C ...	Mutations
P27540	ARNT, BHLHE2	ESCHERICHIA COLI BL21(DE3)	HUMAN	ARNT PROTEIN, CLASS E BASIC HELIX-LOOP-HELIX PROTE ...	Mutations
P15121	EPAS1, BHLHE73, HIF2A, MOP2, PASD2	ESCHERICHIA COLI BL21(DE3)	HUMAN	EPAS-1, BASIC-HELIX-LOOP-HELIX-PAS PROTEIN MOP2, C ...
P27540	ARNT, BHLHE2	ESCHERICHIA COLI BL21(DE3)	HUMAN	ARNT PROTEIN, CLASS E BASIC HELIX-LOOP-HELIX PROTE ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402