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GENERAL
TITLE
NANOMOLAR INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE 1: SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTALLOGRAPHIC STUDIES
DATE LAST MODIFIED
1 Apr 2015
RELEASE
25 Mar 2015
OBSOLETE
CLASSIFICATION
LIGASE/LIGASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
3.3
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1016/J.BMCL.2015.02.035
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P9WN38 GLNA1, GLNA, MT2278 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
GLUTAMATE--AMMONIA LIGASE 1
Mutations
O08600 GLNA1, GLNA, MT2278 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
GLUTAMATE--AMMONIA LIGASE 1
P9WN38 GLNA1, GLNA, MT2278 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
GLUTAMATE--AMMONIA LIGASE 1
Mutations
O08600 GLNA1, GLNA, MT2278 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
GLUTAMATE--AMMONIA LIGASE 1
P9WFK7 GLNA1, GLNA, MT2278 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
GLUTAMATE--AMMONIA LIGASE 1
P46011 GLNA1, GLNA, MT2278 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
GLUTAMATE--AMMONIA LIGASE 1
P9WN38 GLNA1, GLNA, MT2278 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
GLUTAMATE--AMMONIA LIGASE 1
Mutations
O08600 GLNA1, GLNA, MT2278 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
GLUTAMATE--AMMONIA LIGASE 1
P9WN38 GLNA1, GLNA, MT2278 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
GLUTAMATE--AMMONIA LIGASE 1
Mutations
P9WN38 GLNA1, GLNA, MT2278 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS
GLUTAMATE--AMMONIA LIGASE 1
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402