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GENERAL
TITLE
DISCOVERY OF VX-509 (DECERNOTINIB): A POTENT AND SELECTIVE JANUS KINASE (JAK) 3 INHIBITOR FOR THE TREATMENT OF AUTOIMMUNE DISEASES
DATE LAST MODIFIED
20 Jul 2016
RELEASE
12 Aug 2015
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 2 2 21
RESOLUTION RANGE HIGH
2.04
RESOLUTION RANGE LOW
69.14
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.5B00301

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P23497 JAK2 SPODOPTERA FRUGIPERDA HUMAN
JANUS KINASE 2,JAK-2
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402