5HA9

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 5HA9_1

Chain 5HA9_A

Chain 5HA9_B

Spin

Focus

Transparency

More Info

GENERAL

TITLE

CRYSTAL STRUCTURE-BASED DESIGN AND DISOVERY OF A NOVEL PARP1 ANTIAGONIST (BL-PA10) THAT INDUCES APOPTOSIS AND INHIBITS METASTASIS IN TRIPLE NEGATIVE BREAST CANCER

DATE LAST MODIFIED

11 Jul 2018

RELEASE

9 Mar 2016

OBSOLETE

CLASSIFICATION

TRANSFERASE/TRANSFERASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 21

RESOLUTION RANGE HIGH

RESOLUTION RANGE LOW

PUBMED ID

28442756

DOI

10.1038/S41598-016-0007-2

PDBe

5HA9

LIGANDS

628 , 2730972 , 1253640

Chains

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	Q6B0I6	PARP1	ESCHERICHIA COLI K-12	HUMAN	PARP-1,ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIK ...
	P09874	PARP1	ESCHERICHIA COLI K-12	HUMAN	PARP-1,ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIK ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402