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GENERAL
TITLE
CRYSTAL STRUCTURE-BASED DESIGN AND DISOVERY OF A NOVEL PARP1 ANTIAGONIST (BL-PA10) THAT INDUCES APOPTOSIS AND INHIBITS METASTASIS IN TRIPLE NEGATIVE BREAST CANCER
DATE LAST MODIFIED
11 Jul 2018
RELEASE
9 Mar 2016
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
4
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1038/S41598-016-0007-2

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P09874 PARP1 ESCHERICHIA COLI K-12 HUMAN
PARP-1,ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIK ...
Mutations
P09874 PARP1 ESCHERICHIA COLI K-12 HUMAN
PARP-1,ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIK ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402