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GENERAL
TITLE
BINDING SITE ELUCIDATION AND STRUCTURE GUIDED DESIGN OF MACROCYCLIC IL-17A ANTAGONISTS
DATE LAST MODIFIED
22 Nov 2017
RELEASE
31 Aug 2016
OBSOLETE
CLASSIFICATION
IMMUNE SYSTEM/INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
1.8
RESOLUTION RANGE LOW
50.5
PUBMED ID
DOI
10.1038/SREP30859
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q16552 IL17A, CTLA8, IL17 ESCHERICHIA COLI HUMAN
IL-17A,CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8 ...
Mutations
Q16552 IL17A, CTLA8, IL17 ESCHERICHIA COLI HUMAN
IL-17A,CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8 ...
Mutations
P01764 -- HOMO SAPIENS HOMO SAPIENS --
-- HOMO SAPIENS HOMO SAPIENS --
P01764 -- HOMO SAPIENS HOMO SAPIENS --
-- -- SYNTHETIC CONSTRUCT --
-- HOMO SAPIENS HOMO SAPIENS --
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402