5K7K

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 5K7K_A

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GENERAL

TITLE

DESIGN AND OPTIMIZATION OF BIARYL ETHER ARYL SULFONAMIDES AS SELECTIVE INHIBITORS OF NAV1.7: DISCOVERY OF CLINICAL CANDIDATE PF-05089771

DATE LAST MODIFIED

6 Sept 2017

RELEASE

7 Jun 2017

OBSOLETE

CLASSIFICATION

OXIDOREDUCTASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

H 3

RESOLUTION RANGE HIGH

2.3

RESOLUTION RANGE LOW

17.33

PUBMED ID

DOI

10.1021/ACS.JMEDCHEM.7B00598

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P0CB53	CYP2C9, CYP2C10	ESCHERICHIA COLI	HUMAN	(R)-LIMONENE 6-MONOOXYGENASE,(S)-LIMONENE 6-MONOOX ...

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402