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GENERAL
TITLE
DESIGN AND OPTIMIZATION OF BIARYL ETHER ARYL SULFONAMIDES AS SELECTIVE INHIBITORS OF NAV1.7: DISCOVERY OF CLINICAL CANDIDATE PF-05089771
DATE LAST MODIFIED
6 Sept 2017
RELEASE
7 Jun 2017
OBSOLETE
CLASSIFICATION
OXIDOREDUCTASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
H 3
RESOLUTION RANGE HIGH
2.3
RESOLUTION RANGE LOW
17.33
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.7B00598

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P11712 CYP2C9, CYP2C10 ESCHERICHIA COLI HUMAN (R)-LIMONENE 6-MONOOXYGENASE,(S)-LIMONENE 6-MONOOXYGENASE,(S)-LIMONENE 7-MONOOXYGENASE,CYPIIC9,CHOLESTEROL 25-HYDROXYLASE,CYTOCHROME P-450MP,CYTOCHROME P450 MP-4,CYTOCHROME P450 MP-8,CYTOCHROME P450 PB-1,S-MEPHENYTOIN 4-HYDROXYLASE HUMAN
(R)-LIMONENE 6-MONOOXYGENASE,(S)-LIMONENE 6-MONOOX ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402