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GENERAL
TITLE
DISCOVERY OF TAK-272: A NOVEL, POTENT AND ORALLY ACTIVE RENIN IN- HIBITOR
DATE LAST MODIFIED
29 Jul 2020
RELEASE
16 Nov 2016
OBSOLETE
CLASSIFICATION
HYDROLASE/HYDROLASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 3
RESOLUTION RANGE HIGH
2.4
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACSMEDCHEMLETT.6B00251

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P00797 REN HOMO SAPIENS HUMAN ANGIOTENSINOGENASE HUMAN
ANGIOTENSINOGENASE
Mutations
P00797 REN HOMO SAPIENS HUMAN ANGIOTENSINOGENASE HUMAN
ANGIOTENSINOGENASE
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402