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5KQF

3D Structure View

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GENERAL
TITLE
(4~{S},6~{S})-4-[2,4-BIS(FLUORANYL)PHENYL]-4-METHYL-6-PYRIMIDIN-5-YL- 5,6-DIHYDRO-1,3-THIAZIN-2-AMINE (COMPOUND 12) BOUND TO BACE1
DATE LAST MODIFIED
5 Oct 2016
RELEASE
7 Sept 2016
OBSOLETE
CLASSIFICATION
HYDROLASE/HYDROLASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 61 2 2
RESOLUTION RANGE HIGH
1.98
RESOLUTION RANGE LOW
88.39
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.6B01012
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P56817 BACE1, BACE, KIAA1149 ESCHERICHIA COLI HUMAN ASPARTYL PROTEASE 2, ASP 2, BETA-SITE AMYLOID PRECURSORPROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, MEMAPSIN-2, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2 HUMAN
ASPARTYL PROTEASE 2, ASP 2, BETA-SITE AMYLOID PREC ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402