5KYA

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 5KYA_1

Bioassembly 5KYA_2

Chain 5KYA_A

Chain 5KYA_B

Chain 5KYA_E

Chain 5KYA_F

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GENERAL

TITLE

BRAIN PENETRANT LIVER X RECEPTOR (LXR) MODULATORS BASED ON A 2,4,5,6- TETRAHYDROPYRROLO[3,4-C]PYRAZOLE CORE

DATE LAST MODIFIED

1 Nov 2017

RELEASE

21 Sept 2016

OBSOLETE

CLASSIFICATION

DNA BINDING PROTEIN

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 21

RESOLUTION RANGE HIGH

2.598

RESOLUTION RANGE LOW

44.48

PUBMED ID

DOI

10.1016/J.BMCL.2016.08.089

PDBe

LIGANDS

Target Protein	Gene	Expression System	Organism	Synonims	Actions
P55055	NR1H2, LXRB, NER, UNR	ESCHERICHIA COLI	HUMAN	LIVER X RECEPTOR BETA,NUCLEAR RECEPTOR NER,NUCLEAR ...	Mutations
P28702	RXRB, NR2B2	ESCHERICHIA COLI	HUMAN	NUCLEAR RECEPTOR SUBFAMILY 2 GROUP B MEMBER 2,RETI ...	Mutations
P05102	NR1H2, LXRB, NER, UNR	ESCHERICHIA COLI	HUMAN	LIVER X RECEPTOR BETA,NUCLEAR RECEPTOR NER,NUCLEAR ...
P28702	RXRB, NR2B2	ESCHERICHIA COLI	HUMAN	NUCLEAR RECEPTOR SUBFAMILY 2 GROUP B MEMBER 2,RETI ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402