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GENERAL
TITLE
DISCOVERY OF NEW NATURAL-PRODUCT-INSPIRED SPIRO-OXINDOLE COMPOUNDS AS ORALLY ACTIVE INHIBITORS OF THE MDM2-P53 INTERACTION: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 6G
DATE LAST MODIFIED
12 Jun 2019
RELEASE
2 Nov 2016
OBSOLETE
CLASSIFICATION
LIGASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 65 2 2
RESOLUTION RANGE HIGH
2.7
RESOLUTION RANGE LOW
87.45
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.6B00900
PDBe
5LAY
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| Q00987 | -- | -- | HUMAN | DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,P53- ... | Mutations | |
| P12497 | -- | -- | HUMAN | DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,P53- ... | ||
| Q5SHP2 | -- | -- | HUMAN | DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,P53- ... | ||
| Q5SHQ5 | -- | -- | HUMAN | DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,P53- ... | ||
| P12497 | -- | -- | HUMAN | DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,P53- ... | ||
| Q5SHN7 | -- | -- | HUMAN | DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,P53- ... |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402