5LS6

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 5LS6_1

Bioassembly 5LS6_2

Bioassembly 5LS6_3

Bioassembly 5LS6_4

Chain 5LS6_A

Chain 5LS6_B

Chain 5LS6_C

Chain 5LS6_D

Chain 5LS6_E

Chain 5LS6_F

Chain 5LS6_G

Chain 5LS6_H

Chain 5LS6_I

Chain 5LS6_J

Chain 5LS6_K

Chain 5LS6_L

Chain 5LS6_Q

Chain 5LS6_R

Chain 5LS6_S

Chain 5LS6_T

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GENERAL

TITLE

STRUCTURE OF HUMAN POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) WITH INHIBITOR

DATE LAST MODIFIED

10 Jul 2019

RELEASE

22 Feb 2017

OBSOLETE

CLASSIFICATION

TRANSFERASE/INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 21

RESOLUTION RANGE HIGH

3.47

RESOLUTION RANGE LOW

68.84

PUBMED ID

27739677

DOI

10.1021/ACS.JMEDCHEM.6B01315

PDBe

5LS6

LIGANDS

2920637 , 20470 , 23

Chains

Target Protein	Gene	Expression System	Organism	Synonims	Actions
B9A064	EZH2, KMT6	ESCHERICHIA COLI K-12	HUMAN	ENX-1,ENHANCER OF ZESTE HOMOLOG 2,LYSINE N-METHYLT ...
P62837	EED	ESCHERICHIA COLI K-12	HUMAN	HEED,WD PROTEIN ASSOCIATING WITH INTEGRIN CYTOPLAS ...
Q15022	SUZ12, CHET9, JJAZ1, KIAA0160	ESCHERICHIA COLI K-12	HUMAN	CHROMATIN PRECIPITATED E2F TARGET 9 PROTEIN,CHET 9 ...	Mutations
Q99497	EZH2, KMT6	ESCHERICHIA COLI K-12	HUMAN	ENX-1,ENHANCER OF ZESTE HOMOLOG 2,LYSINE N-METHYLT ...
Q6ZSG1	EED	ESCHERICHIA COLI K-12	HUMAN	HEED,WD PROTEIN ASSOCIATING WITH INTEGRIN CYTOPLAS ...
Q15022	SUZ12, CHET9, JJAZ1, KIAA0160	ESCHERICHIA COLI K-12	HUMAN	CHROMATIN PRECIPITATED E2F TARGET 9 PROTEIN,CHET 9 ...	Mutations
O34453	EZH2, KMT6	ESCHERICHIA COLI K-12	HUMAN	ENX-1,ENHANCER OF ZESTE HOMOLOG 2,LYSINE N-METHYLT ...
R9RL27	EED	ESCHERICHIA COLI K-12	HUMAN	HEED,WD PROTEIN ASSOCIATING WITH INTEGRIN CYTOPLAS ...
P12277	SUZ12, CHET9, JJAZ1, KIAA0160	ESCHERICHIA COLI K-12	HUMAN	CHROMATIN PRECIPITATED E2F TARGET 9 PROTEIN,CHET 9 ...
Q15910	EZH2, KMT6	ESCHERICHIA COLI K-12	HUMAN	ENX-1,ENHANCER OF ZESTE HOMOLOG 2,LYSINE N-METHYLT ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402