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GENERAL
TITLE
APPLICATION OF OFF-RATE SCREENING IN THE IDENTIFICATION OF NOVEL PAN- ISOFORM INHIBITORS OF PYRUVATE DEHYDROGENASE KINASE
DATE LAST MODIFIED
5 Apr 2017
RELEASE
22 Feb 2017
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 64
RESOLUTION RANGE HIGH
2.4
RESOLUTION RANGE LOW
29.37
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.6B01478
PDBe
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Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q15119 PDK2, PDHK2 ESCHERICHIA COLI BL21(DE3) HUMAN PYRUVATE DEHYDROGENASE KINASE ISOFORM 2,PDKII HUMAN
PYRUVATE DEHYDROGENASE KINASE ISOFORM 2,PDKII
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402