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GENERAL
TITLE
A PROTEASE-RESISTANT N24S ESCHERICHIA COLI ASPARAGINASE MUTANT WITH OUTSTANDING STABILITY AND ENHANCED ANTI-LEUKAEMIC ACTIVITY
DATE LAST MODIFIED
16 Oct 2019
RELEASE
15 Nov 2017
OBSOLETE
CLASSIFICATION
HYDROLASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
1.427
RESOLUTION RANGE LOW
48.16
PUBMED ID
DOI
10.1038/S41598-017-15075-4
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P00805 ANSB, B2957, JW2924 ESCHERICHIA COLI BL21(DE3) ESCHERICHIA COLI L-ASPARAGINASE II,L-ASNASE II,L-ASPARAGINE AMIDOHYDROLASEII ESCHERICHIA COLI
L-ASPARAGINASE II,L-ASNASE II,L-ASPARAGINE AMIDOHY ...
Mutations
P00805 ANSB, B2957, JW2924 ESCHERICHIA COLI BL21(DE3) ESCHERICHIA COLI L-ASPARAGINASE II,L-ASNASE II,L-ASPARAGINE AMIDOHYDROLASEII ESCHERICHIA COLI
L-ASPARAGINASE II,L-ASNASE II,L-ASPARAGINE AMIDOHY ...
Mutations
P00805 ANSB, B2957, JW2924 ESCHERICHIA COLI BL21(DE3) ESCHERICHIA COLI L-ASPARAGINASE II,L-ASNASE II,L-ASPARAGINE AMIDOHYDROLASEII ESCHERICHIA COLI
L-ASPARAGINASE II,L-ASNASE II,L-ASPARAGINE AMIDOHY ...
Mutations
P00805 ANSB, B2957, JW2924 ESCHERICHIA COLI BL21(DE3) ESCHERICHIA COLI L-ASPARAGINASE II,L-ASNASE II,L-ASPARAGINE AMIDOHYDROLASEII ESCHERICHIA COLI
L-ASPARAGINASE II,L-ASNASE II,L-ASPARAGINE AMIDOHY ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402