5MW4

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 5MW4_A

Chain 5MW4_B

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GENERAL

TITLE

CRYSTAL STRUCTURE OF DOT1L IN COMPLEX WITH INHIBITOR CPD7 [N-(3-(((R)- 1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-3-YL)(METHYL)AMINO) PROPYL)-2-(3-(2-CHLORO-3-(2-METHYLPYRIDIN-3-YL)BENZO[B]THIOPHEN-5- YL)UREIDO)ACETAMIDE]

DATE LAST MODIFIED

5 Apr 2017

RELEASE

22 Mar 2017

OBSOLETE

CLASSIFICATION

TRANSFERASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 63

RESOLUTION RANGE HIGH

2.19

RESOLUTION RANGE LOW

PUBMED ID

28337327

DOI

10.1021/ACSMEDCHEMLETT.6B00519

PDBe

5MW4

LIGANDS

2952263 , 2730972

Chains

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P60568	DOT1L, KIAA1814, KMT4	ESCHERICHIA COLI	HUMAN	DOT1-LIKE PROTEIN,HISTONE H3-K79 METHYLTRANSFERASE ...
	P06762	DOT1L, KIAA1814, KMT4	ESCHERICHIA COLI	HUMAN	DOT1-LIKE PROTEIN,HISTONE H3-K79 METHYLTRANSFERASE ...

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402