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GENERAL
TITLE
HOMODIMERIZATION OF TIE2 FIBRONECTIN-LIKE DOMAINS 1-3 IN SPACE GROUP C2
DATE LAST MODIFIED
29 Jul 2020
RELEASE
26 Apr 2017
OBSOLETE
CLASSIFICATION
SIGNALING PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
2.9
RESOLUTION RANGE LOW
30
PUBMED ID
DOI
10.1073/PNAS.1616166114

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q02763 TEK, TIE2, VMCM, VMCM1 SPODOPTERA AFF. FRUGIPERDA 2 RZ-2014 HUMAN ENDOTHELIAL TYROSINE KINASE,TUNICA INTERNA ENDOTHELIAL CELLKINASE,TYROSINE KINASE WITH IG AND EGF HOMOLOGY DOMAINS-2,TYROSINE-PROTEIN KINASE RECEPTOR TEK,TYROSINE-PROTEIN KINASE RECEPTOR TIE-2,HTIE2,P140 TEKINCLUDES MELLITIN SIGNAL PEPTIDE, A N-TERMINAL CLONING ARTEFACT(ADP), C-TERMINAL FACTOR XA CLEAVAGE SITE (IEGR) AND HIS-TAG. THEFIRST FN-LIKE DOMAIN IN CHAIN B WAS DISORDERED DUE TO LACK OF CRYSTALPACKING CONTACTS AND WAS OMITTED FROM MODEL BUILDING. HUMAN
ENDOTHELIAL TYROSINE KINASE,TUNICA INTERNA ENDOTHE ...
Mutations
Q02763 TEK, TIE2, VMCM, VMCM1 SPODOPTERA AFF. FRUGIPERDA 2 RZ-2014 HUMAN ENDOTHELIAL TYROSINE KINASE,TUNICA INTERNA ENDOTHELIAL CELLKINASE,TYROSINE KINASE WITH IG AND EGF HOMOLOGY DOMAINS-2,TYROSINE-PROTEIN KINASE RECEPTOR TEK,TYROSINE-PROTEIN KINASE RECEPTOR TIE-2,HTIE2,P140 TEKINCLUDES MELLITIN SIGNAL PEPTIDE, A N-TERMINAL CLONING ARTEFACT(ADP), C-TERMINAL FACTOR XA CLEAVAGE SITE (IEGR) AND HIS-TAG. THEFIRST FN-LIKE DOMAIN IN CHAIN B WAS DISORDERED DUE TO LACK OF CRYSTALPACKING CONTACTS AND WAS OMITTED FROM MODEL BUILDING. HUMAN
ENDOTHELIAL TYROSINE KINASE,TUNICA INTERNA ENDOTHE ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402