5NVX

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 5NVX_1

Bioassembly 5NVX_2

Bioassembly 5NVX_3

Bioassembly 5NVX_4

Chain 5NVX_A

Chain 5NVX_B

Chain 5NVX_C

Chain 5NVX_D

Chain 5NVX_E

Chain 5NVX_F

Chain 5NVX_G

Chain 5NVX_H

Chain 5NVX_I

Chain 5NVX_J

Chain 5NVX_K

Chain 5NVX_L

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GENERAL

TITLE

PVHL:ELOB:ELOC IN COMPLEX WITH (2S,4R)-1-((S)-2-(1- FLUOROCYCLOPROPANECARBOXAMIDO)-3,3-DIMETHYLBUTANOYL)-4-HYDROXY-N-(4- (4-METHYLTHIAZOL-5-YL)BENZYL)PYRROLIDINE-2-CARBOXAMIDE (LIGAND 10)

DATE LAST MODIFIED

7 Feb 2018

RELEASE

20 Sept 2017

OBSOLETE

CLASSIFICATION

LIGASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 41 2 2

RESOLUTION RANGE HIGH

2.2

RESOLUTION RANGE LOW

PUBMED ID

28853884

DOI

10.1021/ACS.JMEDCHEM.7B00675

PDBe

5NVX

LIGANDS

710285 , 2692073

Chains

Target Protein	Gene	Expression System	Organism	Synonims	Actions
P9WMC0	ELOB, TCEB2	ESCHERICHIA COLI	HUMAN	ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Q15369	ELOC, TCEB1	ESCHERICHIA COLI	HUMAN	ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRAN ...	Mutations
Q9Y2M0	VHL	ESCHERICHIA COLI	HUMAN	PROTEIN G7,PVHL
Q8U1K8	ELOB, TCEB2	ESCHERICHIA COLI	HUMAN	ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Q15369	ELOC, TCEB1	ESCHERICHIA COLI	HUMAN	ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRAN ...	Mutations
P40337	VHL	ESCHERICHIA COLI	HUMAN	PROTEIN G7,PVHL	Mutations
Q15370	ELOB, TCEB2	ESCHERICHIA COLI	HUMAN	ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRAN ...	Mutations
Q15369	ELOC, TCEB1	ESCHERICHIA COLI	HUMAN	ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRAN ...	Mutations
Q9Y2M0	VHL	ESCHERICHIA COLI	HUMAN	PROTEIN G7,PVHL
Q8U1K8	ELOB, TCEB2	ESCHERICHIA COLI	HUMAN	ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRAN ...

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402