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GENERAL
TITLE
COCRYSTAL STRUCTURE OF THE HUMAN ACYL PROTEIN THIOESTERASE 2 WITH AN ISOFORM-SELECTIVE INHIBITOR, ML349
DATE LAST MODIFIED
4 Dec 2019
RELEASE
26 Oct 2016
OBSOLETE
CLASSIFICATION
HYDROLASE/HYDROLASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
1.64
RESOLUTION RANGE LOW
55.81
PUBMED ID
DOI
10.1021/ACSCHEMBIO.6B00720
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
O95372 LYPLA2, APT2 ESCHERICHIA COLI HUMAN APT-2,LYSOPHOSPHOLIPASE II,LYSOPLA II HUMAN
APT-2,LYSOPHOSPHOLIPASE II,LYSOPLA II
Mutations
O95372 LYPLA2, APT2 ESCHERICHIA COLI HUMAN APT-2,LYSOPHOSPHOLIPASE II,LYSOPLA II HUMAN
APT-2,LYSOPHOSPHOLIPASE II,LYSOPLA II
Mutations
O95372 LYPLA2, APT2 ESCHERICHIA COLI HUMAN APT-2,LYSOPHOSPHOLIPASE II,LYSOPLA II HUMAN
APT-2,LYSOPHOSPHOLIPASE II,LYSOPLA II
Mutations
O95372 LYPLA2, APT2 ESCHERICHIA COLI HUMAN APT-2,LYSOPHOSPHOLIPASE II,LYSOPLA II HUMAN
APT-2,LYSOPHOSPHOLIPASE II,LYSOPLA II
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402