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GENERAL
TITLE
EXPLOITING AN ASP-GLU SWITCH IN GLYCOGEN SYNTHASE KINASE 3 TO DESIGN PARALOG SELECTIVE INHIBITORS FOR USE IN ACUTE MYELOID LEUKEMIA
DATE LAST MODIFIED
8 May 2019
RELEASE
21 Feb 2018
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
2.85
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1126/SCITRANSLMED.AAM8460

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P49841 GSK3B SPODOPTERA FRUGIPERDA HUMAN
GSK-3 BETA,SERINE/THREONINE-PROTEIN KINASE GSK3B
Mutations
P49841 GSK3B SPODOPTERA FRUGIPERDA HUMAN
GSK-3 BETA,SERINE/THREONINE-PROTEIN KINASE GSK3B
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402