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GENERAL
TITLE
THE PROTAC MZ1 IN COMPLEX WITH THE SECOND BROMODOMAIN OF BRD4 AND PVHL:ELONGINC:ELONGINB
DATE LAST MODIFIED
26 Apr 2017
RELEASE
8 Mar 2017
OBSOLETE
CLASSIFICATION
LIGASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 32
RESOLUTION RANGE HIGH
2.7
RESOLUTION RANGE LOW
48.21
PUBMED ID
DOI
10.1038/NCHEMBIO.2329
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
O60885 BRD4, HUNK1 ESCHERICHIA COLI BL21(DE3) HUMAN PROTEIN HUNK1 HUMAN
PROTEIN HUNK1
Mutations
Q15370 TCEB2 ESCHERICHIA COLI BL21(DE3) HUMAN ELONGIN 18 KDA SUBUNIT,ELONGIN-B,ELOB,RNA POLYMERASE IITRANSCRIPTION FACTOR SIII SUBUNIT B,SIII P18 HUMAN
ELONGIN 18 KDA SUBUNIT,ELONGIN-B,ELOB,RNA POLYMERA ...
Mutations
Q15369 TCEB1 ESCHERICHIA COLI BL21(DE3) HUMAN ELONGIN 15 KDA SUBUNIT,ELONGIN-C,ELOC,RNA POLYMERASE IITRANSCRIPTION FACTOR SIII SUBUNIT C,SIII P15 HUMAN
ELONGIN 15 KDA SUBUNIT,ELONGIN-C,ELOC,RNA POLYMERA ...
Mutations
P40337 VHL ESCHERICHIA COLI BL21(DE3) HUMAN PROTEIN G7,PVHL HUMAN
PROTEIN G7,PVHL
Mutations
O60885 BRD4, HUNK1 ESCHERICHIA COLI BL21(DE3) HUMAN PROTEIN HUNK1 HUMAN
PROTEIN HUNK1
Mutations
Q15370 TCEB2 ESCHERICHIA COLI BL21(DE3) HUMAN ELONGIN 18 KDA SUBUNIT,ELONGIN-B,ELOB,RNA POLYMERASE IITRANSCRIPTION FACTOR SIII SUBUNIT B,SIII P18 HUMAN
ELONGIN 18 KDA SUBUNIT,ELONGIN-B,ELOB,RNA POLYMERA ...
Mutations
Q15369 TCEB1 ESCHERICHIA COLI BL21(DE3) HUMAN ELONGIN 15 KDA SUBUNIT,ELONGIN-C,ELOC,RNA POLYMERASE IITRANSCRIPTION FACTOR SIII SUBUNIT C,SIII P15 HUMAN
ELONGIN 15 KDA SUBUNIT,ELONGIN-C,ELOC,RNA POLYMERA ...
Mutations
P40337 VHL ESCHERICHIA COLI BL21(DE3) HUMAN PROTEIN G7,PVHL HUMAN
PROTEIN G7,PVHL
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402