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GENERAL
TITLE
DISCOVERY OF A POTENT CYCLOPHILIN INHIBITOR (COMPOUND 5) BASED ON STRUCTURAL SIMPLIFICATION OF SANGLIFEHRIN A
DATE LAST MODIFIED
29 Mar 2017
RELEASE
25 Jan 2017
OBSOLETE
CLASSIFICATION
ISOMERASE/ISOMERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 2 2 21
RESOLUTION RANGE HIGH
2
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.6B01329
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P62937 PPIA, CYPA BACTERIA HUMAN PPIASE A,CYCLOPHILIN A,CYCLOSPORIN A-BINDING PROTEIN,ROTAMASE A HUMAN
PPIASE A,CYCLOPHILIN A,CYCLOSPORIN A-BINDING PROTE ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402