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GENERAL
TITLE
STRUCTURE-BASED OPTIMIZATION OF 1H-IMIDAZOLE-2-CARBOXAMIDES AS AXL KINASE INHIBITORS UTILIZING A MER MUTANT SURROGATE
DATE LAST MODIFIED
-
RELEASE
25 Jan 2017
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
2.24
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1016/J.BMCL.2016.12.024
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q12866 MERTK, MER ESCHERICHIA COLI HUMAN PROTO-ONCOGENE C-MER,RECEPTOR TYROSINE KINASE MERTK HUMAN
PROTO-ONCOGENE C-MER,RECEPTOR TYROSINE KINASE MERT ...
Mutations
Q12866 MERTK, MER ESCHERICHIA COLI HUMAN PROTO-ONCOGENE C-MER,RECEPTOR TYROSINE KINASE MERTK HUMAN
PROTO-ONCOGENE C-MER,RECEPTOR TYROSINE KINASE MERT ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402