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TITLE
NOVEL BINDING MODES OF INHIBITION OF WILD-TYPE IDH1: ALLOSTERIC INHIBITION WITH CMPD2
EXPRESSION SYSTEM(S)
ESCHERICHIA COLI ,
EXPERIMENT TYPE
X-RAY DIFFRACTION
ORGANISM(S)
HOMO SAPIENS ,
CLASSIFICATION
OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
SPACE GROUP:
C 1 2 1
RESOLUTION RANGE HIGH:
2.17
RESOLUTION RANGE LOW:
137.44
DOI:
10.1021/ACS.JMEDCHEM.8B00305
EM DATA RESOURCE:
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DATE DEPOSITED:
2017-11-09 00:00:00
DATE RELEASED:
2018-07-25 00:00:00
DATE REVISED:
2018-08-22 00:00:00
BIOLOGICAL ASSEMBLY:
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3D Structure - 6BKY

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6BKY_F
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Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonyms
6BKY_E O75874 IDH1, PICD ESCHERICHIA COLI HUMAN IDH,CYTOSOLIC NADP-ISOCITRATE DEHYDROGENASE,IDP,NADP(+)-SPECIFIC ICDH,OXALOSUCCINATE DECARBOXYLASE
6BKY_C O75874 IDH1, PICD ESCHERICHIA COLI HUMAN IDH,CYTOSOLIC NADP-ISOCITRATE DEHYDROGENASE,IDP,NADP(+)-SPECIFIC ICDH,OXALOSUCCINATE DECARBOXYLASE
6BKY_A O75874 IDH1, PICD ESCHERICHIA COLI HUMAN IDH,CYTOSOLIC NADP-ISOCITRATE DEHYDROGENASE,IDP,NADP(+)-SPECIFIC ICDH,OXALOSUCCINATE DECARBOXYLASE
6BKY_D O75874 IDH1, PICD ESCHERICHIA COLI HUMAN IDH,CYTOSOLIC NADP-ISOCITRATE DEHYDROGENASE,IDP,NADP(+)-SPECIFIC ICDH,OXALOSUCCINATE DECARBOXYLASE
6BKY_B O75874 IDH1, PICD ESCHERICHIA COLI HUMAN IDH,CYTOSOLIC NADP-ISOCITRATE DEHYDROGENASE,IDP,NADP(+)-SPECIFIC ICDH,OXALOSUCCINATE DECARBOXYLASE
6BKY_F O75874 IDH1, PICD ESCHERICHIA COLI HUMAN IDH,CYTOSOLIC NADP-ISOCITRATE DEHYDROGENASE,IDP,NADP(+)-SPECIFIC ICDH,OXALOSUCCINATE DECARBOXYLASE