6CKC

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 6CKC_A

Chain 6CKC_B

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GENERAL

TITLE

STRUCTURE OF PRMT5:MEP50 IN COMPLEX WITH LLY-283, A POTENT AND SELECTIVE INHIBITOR OF PRMT5, WITH ANTITUMOR ACTIVITY

DATE LAST MODIFIED

8 Aug 2018

RELEASE

16 May 2018

OBSOLETE

CLASSIFICATION

TRANSFERASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

I 2 2 2

RESOLUTION RANGE HIGH

2.8

RESOLUTION RANGE LOW

PUBMED ID

DOI

10.1021/ACSMEDCHEMLETT.8B00014

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P32379	PRMT5, HRMT1L5, IBP72, JBP1, SKB1	SPODOPTERA FRUGIPERDA	HUMAN	72 KDA ICLN-BINDING PROTEIN,HISTONE-ARGININE N-MET ...
	P32379	WDR77, MEP50, WD45, HKMT1069, NBLA10071	SPODOPTERA FRUGIPERDA	HUMAN	MEP-50,ANDROGEN RECEPTOR COFACTOR P44,WD REPEAT-CO ...

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402