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GENERAL
TITLE
CRYSTAL STRUCTURE OF TYROSINE-PROTEIN KINASE RECEPTOR IN COMPLEX WITH 5-(4-FLUOROPHENYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE INHIBITOR
DATE LAST MODIFIED
1 May 2019
RELEASE
2 May 2018
OBSOLETE
CLASSIFICATION
TRANSFERASE/INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
1.87
RESOLUTION RANGE LOW
39.15
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B00280

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P04629 NTRK1, MTC, TRK, TRKA INSECT CELL EXPRESSION VECTOR PTIE1 HUMAN NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1,TRK1-TRANSFORMING TYROSINE KINASE PROTEIN,TROPOMYOSIN-RELATED KINASE A,TYROSINE KINASE RECEPTOR,TYROSINE KINASE RECEPTOR A,TRK-A,GP140TRK,P140-TRKA HUMAN
NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1,TRK1- ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402