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GENERAL
TITLE
DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE- BASED DESIGN
DATE LAST MODIFIED
18 Dec 2019
RELEASE
5 Sept 2018
OBSOLETE
CLASSIFICATION
DNA BINDING PROTEIN/INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 2
RESOLUTION RANGE HIGH
1.83
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B00375
PDBe
6D9X
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| Q9KMA5 | WDR5, BIG3 | ESCHERICHIA COLI | HUMAN | BMP2-INDUCED 3-KB GENE PROTEIN |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402