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GENERAL
TITLE
CRYSTAL STRUCTURE OF TRK-A IN COMPLEX WITH THE PAN-TRK KINASE INHIBITOR, COMPOUND 10B.
DATE LAST MODIFIED
15 Aug 2018
RELEASE
11 Jul 2018
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
2.68
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B00633
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P04629 NTRK1, MTC, TRK, TRKA SPODOPTERA FRUGIPERDA HUMAN NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1,TRK1-TRANSFORMING TYROSINE KINASE PROTEIN,TROPOMYOSIN-RELATED KINASE A,TYROSINE KINASE RECEPTOR,TYROSINE KINASE RECEPTOR A,TRK-A,GP140TRK,P140-TRKA HUMAN
NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1,TRK1- ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402