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GENERAL
TITLE
POTENT AND SELECTIVE ALDO-KETO REDUCTASE 1C3 (AKR1C3) INHIBITORS BASED ON THE BENZOISOXAZOLE MOIETY: APPLICATION OF A BIOISOSTERIC SCAFFOLD HOPPING APPROACH TO FLUFENAMIC ACID
DATE LAST MODIFIED
11 Apr 2018
RELEASE
4 Apr 2018
OBSOLETE
CLASSIFICATION
OXIDOREDUCTASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
1.3
RESOLUTION RANGE LOW
80.11
PUBMED ID
DOI
10.1016/J.EJMECH.2018.03.040
PDBe
6F78
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| P42330 | AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS | ESCHERICHIA COLI | HUMAN | 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 5,17-BET ... | Mutations | |
| P42330 | AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS | ESCHERICHIA COLI | HUMAN | 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 5,17-BET ... | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402