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GENERAL
TITLE
CRYSTAL STRUCTURE OF AN ENGINEERED BOTULINUM NEUROTOXIN TYPE B MUTANT E1191M/S1199Y IN COMPLEX WITH HUMAN SYNAPTOTAGMIN 2
DATE LAST MODIFIED
11 Aug 2021
RELEASE
16 Jan 2019
OBSOLETE
CLASSIFICATION
TOXIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 2 2 21
RESOLUTION RANGE HIGH
2
RESOLUTION RANGE LOW
57.5
PUBMED ID
DOI
10.1126/SCIADV.AAU7196

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P10844 BOTB ESCHERICHIA COLI BL21(DE3) CLOSTRIDIUM BOTULINUM BONT/B,BONTOXILYSIN-BE231Q/H234Y) BOTULINUM TOXIN TYPE B MUTANT E1191M/S1199Y. PLEASE NOTETHE PROTEIN IS EXPRESSED AS A SINGLE POLYPEPTIDE WHICH IS POST-TRANSLATIONALLY CLEAVED INTO A DI-CHAIN MOLECULE (LIGHT AND HEAVYCHAINS - CHAIN A AND B) CLOSTRIDIUM BOTULINUM
BONT/B,BONTOXILYSIN-BE231Q/H234Y) BOTULINUM TOXIN ...
Mutations
P10844 BOTB ESCHERICHIA COLI BL21(DE3) CLOSTRIDIUM BOTULINUM BONT/B,BONTOXILYSIN-BE231Q/H234Y) BOTULINUM TOXIN TYPE B MUTANT E1191M/S1199Y. PLEASE NOTETHE PROTEIN IS EXPRESSED AS A SINGLE POLYPEPTIDE WHICH IS POST-TRANSLATIONALLY CLEAVED INTO A DI-CHAIN MOLECULE (LIGHT AND HEAVYCHAINS - CHAIN A AND B) CLOSTRIDIUM BOTULINUM
BONT/B,BONTOXILYSIN-BE231Q/H234Y) BOTULINUM TOXIN ...
Mutations
Q8N9I0 -- -- HUMAN SYNAPTOTAGMIN II,SYTII2 RESIDUES [37-57] HUMAN
SYNAPTOTAGMIN II,SYTII2 RESIDUES [37-57]
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402