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GENERAL
TITLE
CRYSTAL STRUCTURE OF AN ENGINEERED BOTULINUM NEUROTOXIN TYPE B MUTANT E1191M/S1199Y IN COMPLEX WITH HUMAN SYNAPTOTAGMIN 2
DATE LAST MODIFIED
11 Aug 2021
RELEASE
16 Jan 2019
OBSOLETE
CLASSIFICATION
TOXIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 2 2 21
RESOLUTION RANGE HIGH
2
RESOLUTION RANGE LOW
57.5
PUBMED ID
DOI
10.1126/SCIADV.AAU7196
PDBe
6G5G
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonyms | Actions | ||
|---|---|---|---|---|---|---|---|---|
| P10844 | BOTB | ESCHERICHIA COLI BL21(DE3) | CLOSTRIDIUM BOTULINUM | BONT/B,BONTOXILYSIN-BE231Q/H234Y) BOTULINUM TOXIN TYPE B MUTANT E1191M/S1199Y. PLEASE NOTETHE PROTEIN IS EXPRESSED AS A SINGLE POLYPEPTIDE WHICH IS POST-TRANSLATIONALLY CLEAVED INTO A DI-CHAIN MOLECULE (LIGHT AND HEAVYCHAINS - CHAIN A AND B) | CLOSTRIDIUM BOTULINUM | BONT/B,BONTOXILYSIN-BE231Q/H234Y) BOTULINUM TOXIN ... | Mutations | |
| P10844 | BOTB | ESCHERICHIA COLI BL21(DE3) | CLOSTRIDIUM BOTULINUM | BONT/B,BONTOXILYSIN-BE231Q/H234Y) BOTULINUM TOXIN TYPE B MUTANT E1191M/S1199Y. PLEASE NOTETHE PROTEIN IS EXPRESSED AS A SINGLE POLYPEPTIDE WHICH IS POST-TRANSLATIONALLY CLEAVED INTO A DI-CHAIN MOLECULE (LIGHT AND HEAVYCHAINS - CHAIN A AND B) | CLOSTRIDIUM BOTULINUM | BONT/B,BONTOXILYSIN-BE231Q/H234Y) BOTULINUM TOXIN ... | Mutations | |
| Q8N9I0 | -- | -- | HUMAN | SYNAPTOTAGMIN II,SYTII2 RESIDUES [37-57] | HUMAN | SYNAPTOTAGMIN II,SYTII2 RESIDUES [37-57] | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402