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GENERAL
TITLE
STRUCTURE OF HUMAN MESOTRYPSIN IN COMPLEX WITH APPI VARIANT T11V/M17R/I18F/F34V
DATE LAST MODIFIED
10 Oct 2018
RELEASE
12 Sept 2018
OBSOLETE
CLASSIFICATION
PROTEIN BINDING
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 31
RESOLUTION RANGE HIGH
2.3
RESOLUTION RANGE LOW
46.09
PUBMED ID
DOI
10.1038/S41467-018-06403-X
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P35030 PRSS3 ESCHERICHIA COLI-PICHIA PASTORIS SHUTTLE VECTOR HUMAN -- HUMAN -- Mutations
P35030 PRSS3 ESCHERICHIA COLI-PICHIA PASTORIS SHUTTLE VECTOR HUMAN -- HUMAN -- Mutations
P05067 APP, A4, AD1 KOMAGATAELLA PHAFFII GS115 HUMAN ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AMYLOIDPRECURSOR PROTEIN,AMYLOID-BETA PRECURSOR PROTEIN,CEREBRAL VASCULARAMYLOID PEPTIDE,CVAP,PREA4,PROTEASE NEXIN-II,PN-II HUMAN
ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AM ...
Mutations
P05067 APP, A4, AD1 KOMAGATAELLA PHAFFII GS115 HUMAN ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AMYLOIDPRECURSOR PROTEIN,AMYLOID-BETA PRECURSOR PROTEIN,CEREBRAL VASCULARAMYLOID PEPTIDE,CVAP,PREA4,PROTEASE NEXIN-II,PN-II HUMAN
ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AM ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402