6GIN logo

6GIN

3D Structure View

Loading...

More Info

GENERAL
TITLE
CRYSTAL STRUCTURE OF THE ACVR1 (ALK2) KINASE IN COMPLEX WITH AN QUINAZOLINONE BASED ALK2 INHIBITOR WITH A 4-MORPHOLINOPHENYL SOLVENT ACCESSIBLE GROUP.
DATE LAST MODIFIED
3 Apr 2019
RELEASE
23 May 2018
OBSOLETE
CLASSIFICATION
SIGNALING PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 2 21 21
RESOLUTION RANGE HIGH
2.2
RESOLUTION RANGE LOW
86.39
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B00782

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q04771 ACVR1, ACVRLK2 SPODOPTERA FRUGIPERDA HUMAN ACTIVIN RECEPTOR TYPE I,ACTR-I,ACTIVIN RECEPTOR-LIKE KINASE2,ALK-2,SERINE/THREONINE-PROTEIN KINASE RECEPTOR R1,SKR1,TGF-BSUPERFAMILY RECEPTOR TYPE I,TSR-I HUMAN
ACTIVIN RECEPTOR TYPE I,ACTR-I,ACTIVIN RECEPTOR-LI ...
Mutations
Q04771 ACVR1, ACVRLK2 SPODOPTERA FRUGIPERDA HUMAN ACTIVIN RECEPTOR TYPE I,ACTR-I,ACTIVIN RECEPTOR-LIKE KINASE2,ALK-2,SERINE/THREONINE-PROTEIN KINASE RECEPTOR R1,SKR1,TGF-BSUPERFAMILY RECEPTOR TYPE I,TSR-I HUMAN
ACTIVIN RECEPTOR TYPE I,ACTR-I,ACTIVIN RECEPTOR-LI ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402