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GENERAL
TITLE
CRYSTAL STRUCTURE OF HUMAN KDR (VEGFR2) KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 18)
DATE LAST MODIFIED
31 Oct 2018
RELEASE
19 Sept 2018
OBSOLETE
CLASSIFICATION
SIGNALING PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
1.87
RESOLUTION RANGE LOW
56.46
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B00938
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P35968 KDR, FLK1, VEGFR2 SPODOPTERA FRUGIPERDA HUMAN VEGFR-2,FETAL LIVER KINASE 1,FLK-1,KINASE INSERT DOMAINRECEPTOR,KDR,PROTEIN-TYROSINE KINASE RECEPTOR FLK-1,VEGFR-2,FETALLIVER KINASE 1,FLK-1,KINASE INSERT DOMAIN RECEPTOR,KDR,PROTEIN-TYROSINE KINASE RECEPTOR FLK-1DELETION OF T940-E990, REPLACED BY A SINGLE VALINE HUMAN
VEGFR-2,FETAL LIVER KINASE 1,FLK-1,KINASE INSERT D ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402