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GENERAL
TITLE
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S1J) IN COMPLEX WITH POSITIVE ALLOSTERIC MODULATOR TDPAM02 AT 1.8 A RESOLUTION
DATE LAST MODIFIED
-
RELEASE
3 Apr 2019
OBSOLETE
CLASSIFICATION
MEMBRANE PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.88
RESOLUTION RANGE LOW
29.58
PUBMED ID
DOI
10.1021/ACSMEDCHEMLETT.8B00369
PDBe
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Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P19491 GRIA2, GLUR2 ESCHERICHIA COLI BL21(DE3) RAT GLUR-2,AMPA-SELECTIVE GLUTAMATE RECEPTOR 2,GLUR-B,GLUR-K2,GLUTAMATE RECEPTOR IONOTROPIC,AMPA 2,GLUA2,GLUR-2,AMPA-SELECTIVEGLUTAMATE RECEPTOR 2,GLUR-B,GLUR-K2,GLUTAMATE RECEPTOR IONOTROPIC,AMPA 2,GLUA2PROTEIN IS THE LIGAND-BINDING DOMAIN OF GLUA2. TRANSMEMBRANE REGIONSARE REPLACED WITH A GLY-THR LINKER (RESIDUES 118-119) AND GLY1-ALA2IS A CLONING REMNANT. THE SEQUENCE MATCHES DISCONTINUOUSLY WITHREFERENCE DATABASE (413-527, 653-797).,NATIVE GLUA2 IS A MEMBRANEPROTEIN. THE CRYSTALLIZED PROTEIN IS THE LIGAND-BINDING DOMAIN OFGLUA2. TRANSMEMBRANE REGIONS ARE REPLACED WITH A GLY-THR LINKER(RESIDUES 118-119) AND GLY1-ALA2 IS A CLONING REMNANT. THE SEQUENCEMATCHES DISCONTINUOUSLY WITH REFERENCE DATABASE (413-527, 653-797). RAT
GLUR-2,AMPA-SELECTIVE GLUTAMATE RECEPTOR 2,GLUR-B, ...
Mutations
P19491 GRIA2, GLUR2 ESCHERICHIA COLI BL21(DE3) RAT GLUR-2,AMPA-SELECTIVE GLUTAMATE RECEPTOR 2,GLUR-B,GLUR-K2,GLUTAMATE RECEPTOR IONOTROPIC,AMPA 2,GLUA2,GLUR-2,AMPA-SELECTIVEGLUTAMATE RECEPTOR 2,GLUR-B,GLUR-K2,GLUTAMATE RECEPTOR IONOTROPIC,AMPA 2,GLUA2PROTEIN IS THE LIGAND-BINDING DOMAIN OF GLUA2. TRANSMEMBRANE REGIONSARE REPLACED WITH A GLY-THR LINKER (RESIDUES 118-119) AND GLY1-ALA2IS A CLONING REMNANT. THE SEQUENCE MATCHES DISCONTINUOUSLY WITHREFERENCE DATABASE (413-527, 653-797).,NATIVE GLUA2 IS A MEMBRANEPROTEIN. THE CRYSTALLIZED PROTEIN IS THE LIGAND-BINDING DOMAIN OFGLUA2. TRANSMEMBRANE REGIONS ARE REPLACED WITH A GLY-THR LINKER(RESIDUES 118-119) AND GLY1-ALA2 IS A CLONING REMNANT. THE SEQUENCEMATCHES DISCONTINUOUSLY WITH REFERENCE DATABASE (413-527, 653-797). RAT
GLUR-2,AMPA-SELECTIVE GLUTAMATE RECEPTOR 2,GLUR-B, ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402