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GENERAL
TITLE
CRYSTAL STRUCTURE OF PROTAC 2 IN COMPLEX WITH THE BROMODOMAIN OF HUMAN SMARCA4 AND PVHL:ELONGINC:ELONGINB
DATE LAST MODIFIED
3 Jul 2019
RELEASE
12 Jun 2019
OBSOLETE
CLASSIFICATION
TRANSCRIPTION
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
1.76
RESOLUTION RANGE LOW
39.8
PUBMED ID
DOI
10.1038/S41589-019-0294-6
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P51532 SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4 ESCHERICHIA COLI BL21(DE3) HUMAN ATP-DEPENDENT HELICASE SMARCA4,BRG1-ASSOCIATED FACTOR 190A,BAF190A,MITOTIC GROWTH AND TRANSCRIPTION ACTIVATOR,PROTEIN BRG-1,PROTEIN BRAHMA HOMOLOG 1,SNF2-BETA,SWI/SNF-RELATED MATRIX-ASSOCIATEDACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 4 HUMAN
ATP-DEPENDENT HELICASE SMARCA4,BRG1-ASSOCIATED FAC ...
Mutations
P40337 VHL ESCHERICHIA COLI BL21(DE3) HUMAN PROTEIN G7,PVHL HUMAN
PROTEIN G7,PVHL
Mutations
Q15369 ELOC, TCEB1 ESCHERICHIA COLI BL21(DE3) HUMAN ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRANSCRIPTIONFACTOR SIII SUBUNIT C,SIII P15,TRANSCRIPTION ELONGATION FACTOR BPOLYPEPTIDE 1 HUMAN
ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Mutations
Q15370 ELOB, TCEB2 ESCHERICHIA COLI BL21(DE3) HUMAN ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRANSCRIPTIONFACTOR SIII SUBUNIT B,SIII P18,TRANSCRIPTION ELONGATION FACTOR BPOLYPEPTIDE 2 HUMAN
ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Mutations
P51532 SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4 ESCHERICHIA COLI BL21(DE3) HUMAN ATP-DEPENDENT HELICASE SMARCA4,BRG1-ASSOCIATED FACTOR 190A,BAF190A,MITOTIC GROWTH AND TRANSCRIPTION ACTIVATOR,PROTEIN BRG-1,PROTEIN BRAHMA HOMOLOG 1,SNF2-BETA,SWI/SNF-RELATED MATRIX-ASSOCIATEDACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 4 HUMAN
ATP-DEPENDENT HELICASE SMARCA4,BRG1-ASSOCIATED FAC ...
Mutations
P40337 VHL ESCHERICHIA COLI BL21(DE3) HUMAN PROTEIN G7,PVHL HUMAN
PROTEIN G7,PVHL
Mutations
Q15369 ELOC, TCEB1 ESCHERICHIA COLI BL21(DE3) HUMAN ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRANSCRIPTIONFACTOR SIII SUBUNIT C,SIII P15,TRANSCRIPTION ELONGATION FACTOR BPOLYPEPTIDE 1 HUMAN
ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Mutations
Q15370 ELOB, TCEB2 ESCHERICHIA COLI BL21(DE3) HUMAN ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRANSCRIPTIONFACTOR SIII SUBUNIT B,SIII P18,TRANSCRIPTION ELONGATION FACTOR BPOLYPEPTIDE 2 HUMAN
ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402