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GENERAL
TITLE
CRYSTAL STRUCTURE OF THE ACVR1 (ALK2) KINASE IN COMPLEX WITH FKBP12 AND THE INHIBITOR E6201
DATE LAST MODIFIED
25 Mar 2020
RELEASE
11 Sept 2019
OBSOLETE
CLASSIFICATION
SIGNALING PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.52
RESOLUTION RANGE LOW
41.32
PUBMED ID
DOI
10.1016/J.CCELL.2020.02.002

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q04771 ACVR1, ACVRLK2 SPODOPTERA FRUGIPERDA HUMAN ACTIVIN RECEPTOR TYPE I,ACTR-I,ACTIVIN RECEPTOR-LIKE KINASE2,ALK-2,SERINE/THREONINE-PROTEIN KINASE RECEPTOR R1,SKR1,TGF-BSUPERFAMILY RECEPTOR TYPE I,TSR-I HUMAN
ACTIVIN RECEPTOR TYPE I,ACTR-I,ACTIVIN RECEPTOR-LI ...
Mutations
P62942 FKBP1A, FKBP1, FKBP12 ESCHERICHIA COLI BL21(DE3) HUMAN PPIASE FKBP1A,12 KDA FK506-BINDING PROTEIN,FKBP-12,CALSTABIN-1,FK506-BINDING PROTEIN 1A,FKBP-1A,IMMUNOPHILIN FKBP12,ROTAMASE HUMAN
PPIASE FKBP1A,12 KDA FK506-BINDING PROTEIN,FKBP-12 ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402