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GENERAL
TITLE
OPTIMIZATION OF POTENT AND SELECTIVE ATM INHIBITORS SUITABLE FOR A PROOF-OF-CONCEPT STUDY IN HUNTINGTON'S DISEASE MODELS
DATE LAST MODIFIED
10 Apr 2019
RELEASE
20 Mar 2019
OBSOLETE
CLASSIFICATION
LYASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 2
RESOLUTION RANGE HIGH
2.09
RESOLUTION RANGE LOW
83.58
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B01819
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q8NEB9 PIK3C3, VPS34 ESCHERICHIA COLI HUMAN PTDINS-3-KINASE TYPE 3,PHOSPHATIDYLINOSITOL 3-KINASE P100SUBUNIT,PHOSPHOINOSITIDE-3-KINASE CLASS 3,HVPS34 HUMAN
PTDINS-3-KINASE TYPE 3,PHOSPHATIDYLINOSITOL 3-KINA ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402