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GENERAL
TITLE
STRUCTURE-BASED DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF IMIDAZO[4,5-B]PYRIDINE-2-ONE BASED P38 MAP KINASE INHIBITORS BY SCAFFOLD HOPPING - COMPOUND 10
DATE LAST MODIFIED
29 May 2019
RELEASE
17 Apr 2019
OBSOLETE
CLASSIFICATION
TRANSFERASE/INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.45
RESOLUTION RANGE LOW
49.38
PUBMED ID
DOI
10.1002/CMDC.201900129
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q16539 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A UNIDENTIFIED BACULOVIRUS HUMAN
MAPK 14,CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRU ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402