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GENERAL
TITLE
BRAF IN COMPLEX WITH N-(3-(2-(2-HYDROXYETHOXY)-6-MORPHOLINOPYRIDIN-4- YL)-4-METHYLPHENYL)-2-(TRIFLUOROMETHYL)ISONICOTINAMIDE (LXH254)
DATE LAST MODIFIED
18 Mar 2020
RELEASE
4 Sept 2019
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 41 21 2
RESOLUTION RANGE HIGH
2.37
RESOLUTION RANGE LOW
46.57
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.9B00161
PDBe
6N0P
LIGANDS
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonyms | Actions | ||
|---|---|---|---|---|---|---|---|---|
| P15056 | BRAF, BRAF1, RAFB1 | UNIDENTIFIED BACULOVIRUS | HUMAN | PROTO-ONCOGENE B-RAF,P94,V-RAF MURINE SARCOMA VIRAL ONCOGENEHOMOLOG B1 | HUMAN | PROTO-ONCOGENE B-RAF,P94,V-RAF MURINE SARCOMA VIRA ... | Mutations | |
| P15056 | BRAF, BRAF1, RAFB1 | UNIDENTIFIED BACULOVIRUS | HUMAN | PROTO-ONCOGENE B-RAF,P94,V-RAF MURINE SARCOMA VIRAL ONCOGENEHOMOLOG B1 | HUMAN | PROTO-ONCOGENE B-RAF,P94,V-RAF MURINE SARCOMA VIRA ... | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402