6P8X

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 6P8X_A

Chain 6P8X_B

Chain 6P8X_C

Chain 6P8X_D

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GENERAL

TITLE

CRYSTAL STRUCTURE OF HUMAN KRAS G12C COVALENTLY BOUND TO AN ACRYLOYLAZETIDINE ACETAMIDE INHIBITOR.

DATE LAST MODIFIED

2 Oct 2019

RELEASE

28 Aug 2019

OBSOLETE

CLASSIFICATION

SIGNALING PROTEIN/INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 1

RESOLUTION RANGE HIGH

2.1

RESOLUTION RANGE LOW

PUBMED ID

DOI

10.1021/ACSMEDCHEMLETT.9B00258

PDBe

LIGANDS

Chains

Target Protein	Gene	Expression System	Organism	Synonims
P0A3M6	KRAS, KRAS2, RASK2	ESCHERICHIA COLI BL21(DE3)	HUMAN	K-RAS 2,KI-RAS,C-K-RAS,C-KI-RAS
O94925	KRAS, KRAS2, RASK2	ESCHERICHIA COLI BL21(DE3)	HUMAN	K-RAS 2,KI-RAS,C-K-RAS,C-KI-RAS
P37798	KRAS, KRAS2, RASK2	ESCHERICHIA COLI BL21(DE3)	HUMAN	K-RAS 2,KI-RAS,C-K-RAS,C-KI-RAS
O94925	KRAS, KRAS2, RASK2	ESCHERICHIA COLI BL21(DE3)	HUMAN	K-RAS 2,KI-RAS,C-K-RAS,C-KI-RAS

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402