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GENERAL
TITLE
HUMAN STEROL 14A-DEMETHYLASE (CYP51) IN COMPLEX WITH THE FUNCTIONALLY IRREVERSIBLE INHIBITOR (R)-N-(1-(3-CHLORO-4'-FLUORO-[1,1'-BIPHENYL]- 4-YL)-2-(1H-IMIDAZOL-1-YL)ETHYL)-4-(5-(3-FLUORO-5-(5-FLUOROPYRIMIDIN- 4-YL)PHENYL)-1,3,4-OXADIAZOL-2-YL)BENZAMIDE
DATE LAST MODIFIED
1 Jan 2020
RELEASE
13 Nov 2019
OBSOLETE
CLASSIFICATION
OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
I 4
RESOLUTION RANGE HIGH
2.8
RESOLUTION RANGE LOW
94.35
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.9B01485
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q16850 CYP51A1, CYP51 ESCHERICHIA COLI HUMAN
LDM, CYPLI, CYTOCHROME P450 51A1, CYTOCHROME P450- ...
Mutations
Q16850 CYP51A1, CYP51 ESCHERICHIA COLI HUMAN
LDM, CYPLI, CYTOCHROME P450 51A1, CYTOCHROME P450- ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402