6SIS

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 6SIS_1

Bioassembly 6SIS_2

Chain 6SIS_A

Chain 6SIS_B

Chain 6SIS_C

Chain 6SIS_D

Chain 6SIS_E

Chain 6SIS_F

Chain 6SIS_G

Chain 6SIS_H

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GENERAL

TITLE

CRYSTAL STRUCTURE OF MACROCYCLIC PROTAC 1 IN COMPLEX WITH THE SECOND BROMODOMAIN OF HUMAN BRD4 AND PVHL:ELONGINC:ELONGINB

DATE LAST MODIFIED

29 Jan 2020

RELEASE

4 Dec 2019

OBSOLETE

CLASSIFICATION

LIGASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 32

RESOLUTION RANGE HIGH

3.5

RESOLUTION RANGE LOW

49.73

PUBMED ID

DOI

10.1002/ANIE.201914396

PDBe

LIGANDS

Chains

Target Protein	Gene	Expression System	Organism	Synonims	Actions
O60885	BRD4, HUNK1	ESCHERICHIA COLI BL21(DE3)	HUMAN	PROTEIN HUNK1	Mutations
P20796	ELOB, TCEB2	ESCHERICHIA COLI BL21(DE3)	HUMAN	ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRAN ...
Q15369	ELOC, TCEB1	ESCHERICHIA COLI BL21(DE3)	HUMAN	ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRAN ...	Mutations
P40337	VHL	ESCHERICHIA COLI BL21(DE3)	HUMAN	PROTEIN G7,PVHL	Mutations
O60885	BRD4, HUNK1	ESCHERICHIA COLI BL21(DE3)	HUMAN	PROTEIN HUNK1	Mutations
Q15370	ELOB, TCEB2	ESCHERICHIA COLI BL21(DE3)	HUMAN	ELOB,ELONGIN 18 KDA SUBUNIT,RNA POLYMERASE II TRAN ...	Mutations
Q15369	ELOC, TCEB1	ESCHERICHIA COLI BL21(DE3)	HUMAN	ELOC,ELONGIN 15 KDA SUBUNIT,RNA POLYMERASE II TRAN ...	Mutations
P40337	VHL	ESCHERICHIA COLI BL21(DE3)	HUMAN	PROTEIN G7,PVHL	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402