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GENERAL
TITLE
DISCOVERY AND OPTIMIZATION OF SALICYCLIC ACID-DERIVED SULFONAMIDE INHIBITORS OF THE WDR5:MYC PROTEIN-PROTEIN INTERACTION
DATE LAST MODIFIED
8 Jan 2020
RELEASE
4 Dec 2019
OBSOLETE
CLASSIFICATION
TRANSCRIPTION
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
1.6
RESOLUTION RANGE LOW
40
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.9B01411
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P61964 WDR5, BIG3 ESCHERICHIA COLI K-12 HUMAN BMP2-INDUCED 3-KB GENE PROTEIN HUMAN
BMP2-INDUCED 3-KB GENE PROTEIN
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402