6USZ

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 6USZ_A

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GENERAL

TITLE

IDENTIFICATION OF THE CLINICAL DEVELOPMENT CANDIDATE MRTX849, A COVALENT KRASG12C INHIBITOR FOR THE TREATMENT OF CANCER

DATE LAST MODIFIED

22 Jul 2020

RELEASE

22 Apr 2020

OBSOLETE

CLASSIFICATION

HYDROLASE/INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 21

RESOLUTION RANGE HIGH

2.03

RESOLUTION RANGE LOW

PUBMED ID

DOI

10.1021/ACS.JMEDCHEM.9B02052

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P15723	KRAS, KRAS2, RASK2	ESCHERICHIA COLI	HUMAN	K-RAS 2,KI-RAS,C-K-RAS,C-KI-RAS

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402