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GENERAL
TITLE
PRMT5 COMPLEX BOUND TO COVALENT PBM INHIBITOR BRD6711
DATE LAST MODIFIED
8 Dec 2021
RELEASE
25 Nov 2020
OBSOLETE
CLASSIFICATION
SPLICING/TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
I 2 2 2
RESOLUTION RANGE HIGH
1.88
RESOLUTION RANGE LOW
45
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.1C00507
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
O14744 PRMT5, HRMT1L5, IBP72, JBP1, SKB1 SPODOPTERA FRUGIPERDA HUMAN 72 KDA ICLN-BINDING PROTEIN,HISTONE-ARGININE N-METHYLTRANSFERASE PRMT5,JAK-BINDING PROTEIN 1,SHK1 KINASE-BINDINGPROTEIN 1 HOMOLOG,SKB1HS HUMAN
72 KDA ICLN-BINDING PROTEIN,HISTONE-ARGININE N-MET ...
Mutations
Q9BQA1 WDR77, MEP50, WD45, HKMT1069, NBLA10071 SPODOPTERA FRUGIPERDA HUMAN MEP-50,ANDROGEN RECEPTOR COFACTOR P44,WD REPEAT-CONTAININGPROTEIN 77,P44/MEP50 HUMAN
MEP-50,ANDROGEN RECEPTOR COFACTOR P44,WD REPEAT-CO ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402