6V94

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 6V94_1

Chain 6V94_A

Chain 6V94_B

Chain 6V94_C

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GENERAL

TITLE

EXPANDING THE CHEMICAL LANDSCAPE OF SOS1 ACTIVATORS USING FRAGMENT BASED METHODS

DATE LAST MODIFIED

RELEASE

26 Aug 2020

OBSOLETE

CLASSIFICATION

SIGNALING PROTEIN

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

I 4 2 2

RESOLUTION RANGE HIGH

1.8

RESOLUTION RANGE LOW

PUBMED ID

DOI

10.1021/ACS.JMEDCHEM.0C00511

PDBe

LIGANDS

Target Protein	Gene	Expression System	Organism	Synonims	Actions
P06746	HRAS, HRAS1	ESCHERICHIA COLI	HUMAN	H-RAS-1,HA-RAS,TRANSFORMING PROTEIN P21,C-H-RAS,P2 ...
Q07889	SOS1	ESCHERICHIA COLI	HUMAN	SOS-1	Mutations
P01112	HRAS, HRAS1	ESCHERICHIA COLI	HUMAN	H-RAS-1,HA-RAS,TRANSFORMING PROTEIN P21,C-H-RAS,P2 ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402