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GENERAL
TITLE
EXPANDING THE CHEMICAL LANDSCAPE OF SOS1 ACTIVATORS USING FRAGMENT BASED METHODS
DATE LAST MODIFIED
-
RELEASE
26 Aug 2020
OBSOLETE
CLASSIFICATION
SIGNALING PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
I 4 2 2
RESOLUTION RANGE HIGH
1.8
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.0C00511

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P01112 HRAS, HRAS1 ESCHERICHIA COLI HUMAN H-RAS-1,HA-RAS,TRANSFORMING PROTEIN P21,C-H-RAS,P21RAS HUMAN
H-RAS-1,HA-RAS,TRANSFORMING PROTEIN P21,C-H-RAS,P2 ...
Mutations
Q07889 SOS1 ESCHERICHIA COLI HUMAN SOS-1 HUMAN
SOS-1
Mutations
P01112 HRAS, HRAS1 ESCHERICHIA COLI HUMAN H-RAS-1,HA-RAS,TRANSFORMING PROTEIN P21,C-H-RAS,P21RAS HUMAN
H-RAS-1,HA-RAS,TRANSFORMING PROTEIN P21,C-H-RAS,P2 ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402