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GENERAL
TITLE
CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN (DBD) OF HUMAN FLI1 AND THE COMPLEX OF THE DBD OF HUMAN RUNX2 WITH CORE BINDING FACTOR BETA (CBFB), IN COMPLEX WITH 16MER DNA CAGAGGATGTGGCTTC
DATE LAST MODIFIED
19 May 2021
RELEASE
25 Nov 2020
OBSOLETE
CLASSIFICATION
TRANSCRIPTION
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 62 2 2
RESOLUTION RANGE HIGH
3.25
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1016/J.STR.2020.11.012
PDBe
6VGD
LIGANDS
--
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonyms | Actions | ||
|---|---|---|---|---|---|---|---|---|
| P11308 | FLI1 | ESCHERICHIA COLI BL21(DE3) | HUMAN | PROTO-ONCOGENE FLI-1,TRANSCRIPTION FACTOR ERGBAFTER ITS CLEAVAGE. | HUMAN | PROTO-ONCOGENE FLI-1,TRANSCRIPTION FACTOR ERGBAFTE ... | ||
| -- | -- | HUMAN | -- | HUMAN | -- | |||
| -- | -- | HUMAN | -- | HUMAN | -- | |||
| Q13950 | RUNX2, AML3, CBFA1, OSF2, PEBP2A | ESCHERICHIA COLI BL21(DE3) | HUMAN | ACUTE MYELOID LEUKEMIA 3 PROTEIN,CORE-BINDING FACTOR SUBUNITALPHA-1,CBF-ALPHA-1,ONCOGENE AML-3,OSTEOBLAST-SPECIFIC TRANSCRIPTIONFACTOR 2,OSF-2,POLYOMAVIRUS ENHANCER-BINDING PROTEIN 2 ALPHA ASUBUNIT,PEBP2-ALPHA A,SL3-3 ENHANCER FACTOR 1 ALPHA A SUBUNIT,SL3/AKVCORE-BINDING FACTOR ALPHA A SUBUNIT | HUMAN | ACUTE MYELOID LEUKEMIA 3 PROTEIN,CORE-BINDING FACT ... | Mutations | |
| Q13951 | CBFB | ESCHERICHIA COLI BL21(DE3) | HUMAN | CBF-BETA,POLYOMAVIRUS ENHANCER-BINDING PROTEIN 2 BETASUBUNIT,PEBP2-BETA,SL3-3 ENHANCER FACTOR 1 SUBUNIT BETA,SL3/AKV CORE-BINDING FACTOR BETA SUBUNITAFFINITY TAG. | HUMAN | CBF-BETA,POLYOMAVIRUS ENHANCER-BINDING PROTEIN 2 B ... | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402