6W50

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 6W50_A

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GENERAL

TITLE

FACTOR XIA IN COMPLEX WITH THE INHIBITOR METHYL ((10R,14S)- 14-(4-(3- CHLORO-2,6-DIFLUOROPHENYL)-6-OXO-3,6-DIHYDRO- 1(2H)-PYRIDINYL)-10- METHYL-9-OXO-8,16- DIAZATRICYCLO[13.3.1.0~2,7~]NONADECA-1(19),2,4,6, 15,17- HEXAEN-5-YL)CARBAMATE

DATE LAST MODIFIED

22 Jul 2020

RELEASE

10 Jun 2020

OBSOLETE

CLASSIFICATION

HYDROLASE/HYDROLASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 32 2 1

RESOLUTION RANGE HIGH

1.95

RESOLUTION RANGE LOW

35.54

PUBMED ID

32456431

DOI

10.1021/ACS.JMEDCHEM.0C00464

PDBe

6W50

LIGANDS

230 , 2730972 , 2047084

Chains

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P03951	F11	ESCHERICHIA COLI BL21(DE3)	HUMAN	FXI, PLASMA THROMBOPLASTIN ANTECEDENT, PTA	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402